Doxorubicin hydrochloride, ≥99%

Catalog No. 107070

Identification

Synonyms	Adriamycin
CAS No.	25316-40-9
M.F.	C₂₇H₂₉NO₁₁·HCl
M.W.	579.98
Beilstein No.	4229251
EC No.	246-818-3
MDL No.	MFCD00077757

Technical Data

Appearance	Orange red powder
Purity	≥99% HPLC
Solubility	Water, Methanol
Storage	2-8℃
Application	Doxorubicin hydrochloride is an antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.

Safety Data

Symbol	GHS08 GHS07
Hazard Statements	H302-H350
Precautionary Statements	P201-P308 + P313
Hazard Symbols	T
Risk Statements	R45-22
Safety Statements	S53-45
WGK Germany	3
RTECS	QI9295900

Reference

Skladanowski and Konopa (1993) Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells. Biochem.Pharmacol. 46 357. PMID: 8347161.

Patel et al (1997) Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cyotoxicity. Mol.Pharmacol. 52 658. PMID: 9380029.

Gewirtz (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem.Pharmacol. 57 727. PMID: 10075079.

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Doxorubicin hydrochloride, ≥99%

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