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CHIR-99021, ≥98%

Catalog No. 586054

General Information
SynonymsGSK-3 Inhibitor XVI, CHIR 99021
CAS No.252917-06-9
M.F.

C22H18Cl2N8

M.W.465.34
Technical Data
AppearanceWhite or light yellow powder
Purity≥98% HPLC
SolubilityDMSO
Storage2-8℃
DescriptionCHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.
Reference

Van der Jeught M, Stem Cells Dev. 22(2):296-306, (2013)
Lian X, et al. Nat Protoc. 8(1):162-75, (2013)
Moraveji SF, et al. Hum Reprod. 27(8):2312-24, (2012)
Xi J, et al. Stem Cells. 30(8):1655-63, (2012)
Ye S, et al. PLoS One. 7(4):e35892, (2012)
Zhang M, et al. BMC Dev Biol. 12:21, (2012)
Domínguez JM, et al. J Biol Chem. 287(2):893-904, (2012)
Marchand B, et al. Carcinogenesis. 33(3):529-37, (2012)
Lian X, et al. Proc Natl Acad Sci U S A. 109(27):E1848-57, (2012)

Size Price Quantity Favorites
100 mg USD280
500 mg USD980
5 g USD2670

Please inquire for non-standard packs and bulk quantities.

Availability: Ships in 1-3 days

For research use only. Not for human use.

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