Cycloheximide, ≥98%

Catalog No. 722818

General Information

Synonyms	Actidione
CAS No.	66-81-9
M.F.	C₁₅H₂₃NO₄
M.W.	281.35

Technical Data

Appearance	White or off-white crystalline powder
Melting Point (°C)	116-121℃
Specific Rotation (°)	-26°~-32°
Assay	≥98%
Solubility	Soluble to 50 mM in ethanol and to 25 mM in water
Storage	2-8℃
Potency	≥980 µg/mg
Biological Activity	Selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T-cells. Competitively inhibits the PPIase hFKBP12 (Ki = 3.4 μM). Antifungal antibiotic.

Safety Data

Symbol	GHS09 GHS08 GHS06
Hazard Statements	H300-H341-H360D-H411
Precautionary Statements	P201-P264-P273-P281-P301 + P310-P308 + P313
Hazard Symbols	N T+
Risk Statements	R61-28-51/53-68
Safety Statements	S53-45-61
UN No.	2811
Hazard Class	6.1
Packing Group	I
RTECS	MA4375000

Reference

1. Obrig et al (1971) The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. J.Biol.Chem. 246 174. PMID: 5541758.

2. Christner et al (1999) Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J.Med.Chem. 42 3615. PMID: 10479292.

3. Tang et al (1999) Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism. J.Biol.Chem. 274 7245. PMID: 10066786.