Celastrol, ≥98%

Catalog No. 877128

Identification

Synonyms	Tripterin
CAS No.	34157-83-0
M.F.	C₂₉H₃₈O₄
M.W.	450.61
MDL No.	MFCD03424073
Botanical Source	Celastrus scandens

Technical Data

Appearance	Red powder
Assay	≥98% HPLC
Solubility	DMSO, Methanol
Storage	2-8℃, protected from light
Application	Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).

Safety Data

Symbol	GHS06
Hazard Statements	H301
Precautionary Statements	P301 + P310
Hazard Symbols	T
Risk Statements	R25
Safety Statements	S45
WGK Germany	2

Reference

Huang, Y. et al. Cancer Lett. 264, 101-106, (2008)
Zhang, T. et al. Mol. Cancer Ther. 7, 162-170, (2008)
Jung, H.W., et al. Exp. Mol. Med. 39, 715-721, (2007)
Yang, H., et al.: Cancer Res., 66, 4758 (2006)
Grosios, K., et al.: Inflamm. Res., 53, 133 (2004)
He, W., et al.: Bioorg. Med. Chem. Lett., 8, 3659 (1998)
Folkman, J., et al.: Nature, 1, 27 (1995)
Senger, D., et al.: Science, 219, 983 (1983)

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Celastrol, ≥98%

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