Luteolin, ≥98%

Catalog No. 622608

Identification

Synonyms	3′,4′,5,7-Tetrahydroxyflavone
CAS No.	491-70-3
M.F.	C₁₅H₁₀O₆
M.W.	286.24
Beilstein No.	292084
EC No.	207-741-0
MDL No.	MFCD00017309
PubChem Substance ID	24896520
Botanical Source	Arachis hypogaea L.

Technical Data

Appearance	Yellow green powder
Melting Point (°C)	~330°C (lit.)
Assay	≥98% HPLC
Solubility	Soluble to 5 mM in 1eq. NaOH and to 50 mM in DMSO
Storage	2-8℃
Biological Activity	Anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo.

Safety Data

Symbol	GHS07
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Symbols	Xi
Risk Statements	R36/37/38
Safety Statements	S26-36
WGK Germany	3
RTECS	LK9275210

Reference

Chen et al (2007) Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage. Life Sci. 81 1602. PMID: 17977562.

Ju et al (2007) A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells. Mol.Pharmacol. 71 1381. PMID: 17296806.

Kim et al (2007) Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann.N.Y.Acad.Sci. 1090 597.

Kim et al (2011) Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J.Pharm.Exp.Ther. 338 1013.

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Luteolin, ≥98%

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