Colchicine, ≥98%

Catalog No. 488504

General Information

CAS No.	64-86-8
M.F.	C₂₂H₂₅NO₆
M.W.	399.44
Beilstein No.	2228813
MDL No.	MFCD00078484
Botanical Source	Colchicum autumnale L.

Technical Data

Appearance	Light yellow powder
Specific Rotation (°)	-240°~-250°(c=1, alcohol)
Assay	≥98%
Solubility	Soluble in water, freely soluble in alcohol and chloroform, slightly soluble in ether
Storage	Room temperature

Safety Data

Symbol	GHS08 GHS06
Hazard Statements	H300-H340
Precautionary Statements	P201-P264-P301 + P310-P308 + P313
Hazard Symbols	T+
Risk Statements	R46-28
Safety Statements	S53-45
UN No.	1544
Hazard Class	6.1
Packing Group	I
WGK Germany	3
RTECS	GH0700000

Reference

Hastie (1991) Interactions of colchicine with tubulin. Pharmacol.Ther. 51 377. PMID: 1792241.

Burns (1992) Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 297 205. PMID: 1544399.

Bai et al (1996) Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colchicine. J.Biol.Chem. 271 12639. PMID: 8647876.